n | Predicted within 2-Fold | Overpredicted | Underpredicted | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Simcyp V11 (Time-Based) | Static Equations | Simcyp V11 (Time-Based) | Static Equations | Simcyp V11 (Time-Based) | Static Equations | |||||
Without Hepatic First-Pass Correction | With Hepatic First-Pass Correction | Without Hepatic First-Pass Correction | With Hepatic First-Pass Correction | Without Hepatic First-Pass Correction | With Hepatic First-Pass Correction | |||||
A | 6 | 3 | 5 | 3 | 2 | 0 | 2 | 1 | 1 | 1 |
B | 8 | 4 | 7 | 6 | 1 | 1 | 2 | 3 | 0 | 0 |
C | 5 | 4 | 4 | N.C. | 0 | 0 | 0 | 1 | 1 | N.C. |
N.C., not calculated.