Species | Total GDC-0980 Concentrationa | Blood-Plasma Ratio of [14C]GDC-0980 |
---|---|---|
μM | ||
Mouse | 1 | 0.75 ± 0.016 |
10 | 0.78 ± 0.049 | |
40 | 0.85 ± 0.041 | |
Rat | 1 | 0.97 ± 0.017 |
10 | 0.92 ± 0.045 | |
40 | 0.90 ± 0.027 | |
Cynomolgus monkey | 1 | 1.1 ± 0.0043 |
10 | 1.1 ± 0.035 | |
40 | 1.0 ± 0.0087 | |
Dog | 1 | 0.94 ± 0.039 |
10 | 0.85 ± 0.013 | |
40 | 0.83 ± 0.0042 | |
Human | 1 | 1.3 ± 0.015 |
10 | 1.1 ± 0.081 | |
40 | 1.1 ± 0.055 |
↵a Unlabeled and 14C-labeled GDC-0980.