Predicted (GastroPlus) and observed AUC, Cmax, and T1/2 in human after administration of a 2-mg oral dose and predicted human dose and parameters associated with 60% tumor growth inhibition
Observed data reported as mean ± S.D. (n = 3) (Wagner et al., 2009).
| Dose | AUC0–24 | Cmax | T1/2 | |||
|---|---|---|---|---|---|---|
| Predicted | Observed | Predicted | Observed | Predicted | Observed | |
| μM·h | μM | h | ||||
| 2 mg | 0.13 | 0.17 (0.06) | 0.017 | 0.019 (0.005) | 4.4 | 6.4 (2.6) |
| 55 mg | 3.8 | 0.43 | 4.4 | |||