Influence of experimental manipulations on the enterohepatic recycling of VPA in rats
Data are presented as mean (S.D.).
| Sprague-Dawley | Wistar | ||||
|---|---|---|---|---|---|
| Vehicle (n = 4) | Charcoal (n = 3) | Antibiotics (n = 5) | Wild Type (n = 4) | Mrp2(−/−) (n = 4) | |
| AUC0–8 h | 124 (6.54) | 133 (14.3) | 145 (30.2) | 102 (10.5) | 94.4 (10.5) |
| AUCpre-ER* | 80.1 (4.73) | 92.8 (8.11) | 126** (26.8) | 54.9 (3.42) | 89.4*** (10.8) |
| AUCER* | 43.5 (4.44) | 39.9 (11.5) | 19.2*** (3.54) | 47.1 (13.6) | 4.91*** (0.862) |
| ΦER* | 0.352 (0.0274) | 0.298 (0.0605) | 0.133*** (0.00894) | 0.456 (0.0868) | 0.0530*** (0.0127) |
| Percentage of control | 91.8 | 44.1 | 10.4 | ||
AUCpre-ER, area under the concentration-time profile before the secondary increase in concentrations and extrapolated through infinite time; AUCER, difference between AUC0–8 h and AUCpre-ER.
↵* P < 0.05 (ANOVA), significantly different among Sprague-Dawley groups.
↵** P < 0.01, significantly different from respective control.
↵*** P < 0.001, significantly different from respective control.