Rat | Monkey | Human | ||||||
---|---|---|---|---|---|---|---|---|
CLinta | CLHEPb | CLpc | CLint | CLHEP | CLp | CLint | CLHEP | |
ml · min−1 · kg−1 | ||||||||
S9 minus NADPH | 25 | 18 | 34 | 19 | 1.0 | 1.0 | ||
S9 + NADPH | 54 | 30 | 37 | 20 | 15 | 8.6 | ||
Cytosol | 16 | 13 | N.A. | N.A. | 3.7 | 3.2 | ||
Hepatocytes | 96 | 40 | 194 | 36 | 6.9 | 5.1 | ||
In vivo | 43 | 24 |
CLint, intrinsic clearance; CLHEP, predicted hepatic clearance; CLp, plasma clearance; N.A., not available.