Empirical scaling factors applied to the active uptake clearances to recover the intrinsic uptake clearance in human livers
| Drug | Scaling Factor | Mean | ||
|---|---|---|---|---|
| HU4122 | HU4199 | HU8089 | ||
| Bosentan | 16.1 | 13.0 | 24.8 | 17.9 ± 6.1 |
| Pravastatin | 6.67 | ND | ND | 6.67 |
| Repaglinide | 4.70 | 39.2 | 17.7 | 20.5 ± 17.4 |
| Rosuvastatin | 9.75 | 51.9 | 65.3 | 42.3 ± 29.0 |
| Telmisartan | 3.23 | 18.7 | 17.9 | 13.3 ± 8.7 |
| Valsartan | 0.740 | 2.00 | 2.20 | 1.64 ± 0.79 |
| Mean | 6.87 ± 5.46 | 25.0 ± 20.2 | 25.6 ± 23.7 | 17.1 ± 18.8 |
N.D., not determined, because CLuptake, u could not be measured accurately at a single concentration.