TABLE 1

Plasma glucose at start of study

Data are in mg/dl. Mean ± S.E. (n = 8–12 per group in combined sexes and 4–6 per group in male or female groups).

Sex	Minutes	HIRMAb-IDUA Injection Dose
		0 mg/kg	3 mg/kg	9 mg/kg	30 mg/kg
Combined	0	83 ± 7	74 ± 4	70 ± 5	78 ± 4
	2	73 ± 3	67 ± 7	67 ± 3	75 ± 4
	5	74 ± 4	64 ± 7	64 ± 3	74 ± 4
	30	75 ± 3	55 ± 6^{^†}	57 ± 4^*	60 ± 3^*
	35	79 ± 5	56 ± 5^{^†}	59 ± 4^*	59 ± 3^{^†}
	90	91 ± 5	75 ± 5	72 ± 4	63 ± 6^{^†}
	180	74 ± 8	58 ± 5	61 ± 3	39 ± 5^{^†}
	360	74 ± 5	72 ± 12	79 ± 11	65 ± 8
	1380	76 ± 5	79 ± 8	69 ± 5	70 ± 8
Male	0	75 ± 7	81 ± 6	72 ± 6	79 ± 7
	2	75 ± 4	78 ± 5	65 ± 7	70 ± 4
	5	76 ± 4	74 ± 6	62 ± 5	69 ± 4
	30	74 ± 3	58 ± 2	56 ± 6^*	57 ± 3^*
	35	75 ± 4	60 ± 3	59 ± 7	58 ± 3^*
	90	86 ± 5	81 ± 6	75 ± 4	62 ± 4^{^†}
	180	65 ± 9	69 ± 4	59 ± 6	37 ± 6^{^†}
	360	66 ± 4	58 ± 5	89 ± 10	70 ± 14
	1380	75 ± 10	89 ± 8	64 ± 5	70 ± 12
Female	0	90 ± 13	68 ± 5	69 ± 9	77 ± 6
	2	70 ± 5	55 ± 9	69 ± 3	80 ± 7
	5	72 ± 7	54 ± 12	67 ± 3	79 ± 7
	30	77 ± 6	52 ± 12	59 ± 4	63 ± 6
	35	82 ± 9	52 ± 11	60 ± 5	61 ± 6
	90	96 ± 8	69 ± 9	70 ± 7	63 ± 11
	180	84 ± 12	47 ± 7	64 ± 2	41 ± 9^*
	360	82 ± 9	87 ± 22	68 ± 20	61 ± 9
	1380	76 ± 5	69 ± 12	75 ± 8	69 ± 13

↵* P < 0.05 difference from 0 mg/kg by analysis of variance.
↵† P < 0.01 difference from 0 mg/kg by analysis of variance.