TABLE 1

Possible models for inhibition of CYP2E1

Model	Complexes Formed	Binding Allostery?		Parameters and Consequences^{^a}
Model	Complexes Formed	Substrate (on Inhibitor)	Inhibitor (on Substrate)	Parameters and Consequences^{^a}
Competitive	ES, ESS, EI	No	No	K_s, K_ss, K_i, k_cat
Uncompetitive	ES, ESS, ESI	No	No	K_s, K_ss, K_si, k_cat1, k_cat2?
Mixed
Allosteric both	ES, ESS, EI, ESI	Yes	Yes	K_s, K_ss, K_i, K_si, K_is, k_cat1, k_cat2?
Allosteric Substrate	ES, ESS, EI, ESI	Yes	No	K_s, K_ss, K_i, K_si, K_is = K_s, k_cat1, k_cat2?
Allosteric inhibitor	ES, ESS, EI, ESI	No	Yes	K_s, K_ss, K_i = K_si, K_is, k_cat1, k_cat2?
Noncompetitive	ES, ESS, EI, ESI	No	No	K_s, K_ss, K_i = K_si, K_is = K_s, k_cat1, k_cat2?

EI, enzyme-inhibitor.
↵a In all models except competitive, ESI may be active or not. Both possibilities were included in discriminations.