TABLE 2

Compartmental pharmacokinetic parameters of RES, R3S, and R3G administered as parent compound using model 1, 2 and 3, respectively

ParametersRES, Model 1R3S, Model 2R3G, Model 3
Estimate, CV%
Vc, RES (l/kg)1.77 (27.29)N/AN/A
Cl, RES (ml · min−1 · kg−1)104.54 (3.97)N/AN/A
k1,0 (min−1)0.06 (25.66)N/AN/A
k1,2 (min−1)0.23 (23.74)N/AN/A
k2,1 (min−1)0.06 (14.74)N/AN/A
k1,3 (min−1)0.09 (24.73)N/AN/A
k3,1 (min−1)0.004 (11.84)N/AN/A
Vc, R3S (l/kg)N/A0.69 (11.43)N/A
Cl, R3S (ml · min−1 · kg−1)N/A63.11 (3.56)N/A
k1,0 R3S (min−1)N/A0.09 (9.37)N/A
k1,2 R3S (min−1)N/A0.15 (7.17)N/A
k2,1 R3S (min−1)N/A0.012 (7.45)N/A
Vc, R3G (l/kg)N/AN/A0.23 (10.95)
Cl, R3G (ml · min−1 · kg−1)N/AN/A10.63 (6.81)
k1,0 R3G (min−1)N/AN/A0.05 (11.86)
k1,2 R3G (min−1)N/AN/A0.04 (15.53)
k2,1 R3G (min−1)N/AN/A0.03 (14.97)
k1,3 R3G (min−1)N/AN/A0.07 (9.06)
k3,1 R3G (min−1)N/AN/A0.002 (11.27)

  • N/A, not applicable.