Half-life of compounds and distribution of metabolites
| Compound | Percentage Remaining after 1 h | Half-Life | Pyridyl N-Oxidation (+16) | Demethylation (−14) | Oxidation on Pyrimidinyl Substructure (+16) | Bis-Oxidation (+32) |
|---|---|---|---|---|---|---|
| min | % | |||||
| 2 | 33.7 | 38 | 59.9% (M2-1) | 15.9%a (M2-2) | 13.8% (M2-3) | 10.3 |
| 3 | 29.2 | 34 | 45.8% (M3-1) | 28.0% (M3-2) | 25.8% (M3-3) <5% (M3-4) | 10.1 |
| 7 | 0 | <10 | 70.5% (M7-1) | 6.3% (M7-2) | 5.3% (M7-3) | 15.1 |
| 8 | 26.5 | 31 | 74.2% (M8-1) | 19.7% (M8-2) | 6.3% (M8-3) | 1.7 |
↵a Percentages based on total AUC.