TABLE 2

Genes exhibiting high interindividual variability (CV > 10%) in primary cultures of HBEC

Interindividual variability in gene expression is evaluated by calculation of the coefficient of variation (CV = ΔCt S.D./mean ΔCt).

GenesMinimum ΔCtMaximum ΔCtCoefficient of Variation
Phase I enzymes
    CYP4B117.0923.8515.41
    CYP2W120.1428.0914.46
    CYP11A122.0428.9113.83
    CYP4A11/2222.0730.5313.78
    ALDH3B217.2923.0112.17
    DHRS221.9728.7112.13
    ALDH1A222.0728.0911.61
    ALDH1A310.4113.8511.61
    CYP26B118.4924.5511.49
    ALDH3A115.7519.9611.16
    FMO323.2928.9110.88
    CYP4F1115.0419.1410.38
    ADH716.3120.7210.27
Phase II enzymes
    GSTT117.3430.5328.58a
    GSTM120.8030.5319.82a
    INMT21.6228.9115.11
    UGT1A1022.5230.5314.66
    GSTT2/2B17.4823.7813.44
    UGT1A823.1030.5312.28
    SULT2B113.0316.9310.89
Transporters
    ABCA420.0828.0915.02
    SLC7A511.6814.8313.06
    SLCO4A116.4121.8612.85
    SLC7A1113.1417.0412.81
    ABCC622.9828.9110.75
    ABCB1122.3327.9810.70
    SLCO5A122.7128.9110.52
Nuclear receptors and other genes
    ARNT219.9326.6414.69
    FOXA217.2922.5713.65
    HIF3A21.2528.7112.34
    MT1X12.0115.7112.61

  • ↵a Underlined genes represent genes that exhibited the highest coefficients of variation.