Drug | AUCECF/AUCp,u | Clin/Clout | Kp,u,ss | keq | t1/2,eq |
---|---|---|---|---|---|
min−1 | min | ||||
Escitalopram | 0.86 (13) | 1.24 (25) | 1.06 (42) | 0.015 (42) | 54 (56) |
Clozapine* | 0.15 (37) | 0.16 (36) | 0.13 (33) | 0.004 (26) | 194 (23) |
N-desmethylclozapine* | 0.03 (74) | 0.05 (60) | 0.04 (85) | 0.006 (87) | 165 (48) |
Risperidone* | 0.15 (9) | 0.14 (16) | 0.21 (39) | 0.006 (72) | 165 (63) |
↵* AUC and Cl ratios, and Kp,u,ss significantly different (p < 0.01) vs. corresponding escitalopram values according to one-way analysis of variance followed by the Tukey t test for multiple comparisons.