AM2201 Metabolites | CLint in rP450 | Hepatic Abundance | Fractional Contribution of Each P450 (fm, CYP) |
---|---|---|---|
CYP1A2 | |||
ω-OH | 19 | 0.11–0.16 | |
ω-COOH | 89 | 0.045–0.052 | 0.26–0.35 |
ω-1-OH | 23 | 0.39–0.49 | |
CYP2C9 | |||
ω-OH | 63 | 0.67–0.76 | |
ω-COOH | 111 | 0.032–0.073 | 0.48–0.70 |
ω-1-OH | 17 | 0.36–0.52 | |
CYP2C19 | |||
ω-OH | 32 | 0.059–0.091 | |
ω-COOH | 28 | 0.006–0.014 | 0.021–0.030 |
ω-1-OH | 0.940 | 0.003–0.010 | |
CYP2D6 | |||
ω-OH | 3.7 | 0.001–0.005 | |
ω-COOH | 0.371 | 0.009–0.01 | 0.0005–0.002 |
ω-1-OH | 0 | 0 |
rP450, recombinant human cytochrome P450.