trans-stimulation of rosuvastatin basolateral efflux in Caco-2 cells
Rosuvastatin (50 μM) and atenolol (10 μM) were codosed into the apical compartment at pH 5.5; rosuvastatin release in the basolateral compartment at pH 7.4 was measured in the absence (control) or the presence of taurolithocholate. Data are expressed as mean ± S.D. (n = 3).
| Treatment | Basolateral Efflux | Percentage of Control |
|---|---|---|
| pmol · min−1 · mg protein−1 | ||
| Control | 14.24 ± 0.34 | 100 |
| +Taurolithocholate, 10 μM | 48.16 ± 13.68* | 338 |
| +Taurolithocholate, 50 μM | 62.12 ± 12.34* | 436 |
| +Taurolithocholate, 100 μM | 51.17 ± 7.13* | 359 |
↵* P < 0.001, significance level of the difference from the control.