TABLE 1

Pharmacokinetic parameters of d-serine (30 mg/kg) administered orally to mice

Cohorts	Dose	T_max	C_max	T_1/2	AUC_last	AUC_0–∞
	mg/kg	h	ng/ml	h	ng · h/ml	ng · h/ml
Wild type	30	0.7 ± 0.3	19,609 ± 1338	1.2 ± 0.1	40,648 ± 6602	46,023 ± 8976
Wild type + CBIO^*	30	1.0	24,277	1.5	65,778	80,899
Knockout	30	2.7 ± 0.9	27,791 ± 2019	>10^†	95,768 ± 6234	—^‡

↵* The S.D. of the data cannot be determined because of the insufficient number (2) of data points at 120 and 240 min.
↵† Insufficient data for accurate approximation.
↵‡ The AUC extrapolated from the AUC_last is greater than 25%; hence, the AUC_0–∞ value is not reported.