Metabolites | Rat | Dog | Human | ||||||
---|---|---|---|---|---|---|---|---|---|
Urine | Feces | Total | Urine | Feces | Total | Urine | Feces | Total | |
Parent | 11.0 | 1.1 | 12.1 | 25.6 | 1.8 | 27.4 | 48.5 | 0.4 | 48.9 |
M1 | 3.1 | 17.8 (11.7) | 20.9 | 1.2 | 4.6 | 5.8 | 3.0 | 3.0 | |
M2 | 3.2 | 2.3 | 5.5 | 2.5 | 2.5 | 1.1 | 1.2 | 2.3 | |
M3 | 1.4 | 1.4 | 0.9 | 0.9 | |||||
M4 | 2.9 | (81.6) | 2.9 | 1.0 | 1.0 | ||||
M5 | 7.3 | 32.3 | 39.6 | 30.1 | 9.0 | 39.1 | 17.9 | 2.7 | 20.6 |
M6 | (2.1) | 2.6* | |||||||
M7 | |||||||||
M8 | 0.6 | ||||||||
M9 | 1.6 | 6.0* | 6.0* | ||||||
M10 | 0.1 | 0.1 | 0.1 | 0.1 | |||||
M11 | 5.5 | 5.5 | |||||||
M12 | 0.2 | (1.3) | 0.2 | ||||||
M13 | 0.2 | 0.2 | |||||||
M14 | 0.2 | 0.2 | |||||||
M15 | 0.9 | 0.9 | |||||||
M16 | * | * | |||||||
M17 | 1.0 | 1.0 | |||||||
M18 | * |
↵* Metabolites M9, M16, and M18 could not be chromatographically resolved in human urine. Metabolites M6 and M7 could not be resolved in dog urine. Parentheses indicates biliary metabolites.