Cell Line | Rosuvastatin | Prazosin | ||||
---|---|---|---|---|---|---|
A-to-B Papp | B-to-A Papp | ER | A-to-B Papp | B-to-A Papp | ER | |
×10−6 cm/s | ×10−6 cm/s | |||||
Caco-2 | 0.25 ± 0.08 | 20.66 ± 3.47 | 83.2 | 3.92 ± 0.28 | 41.10 ± 5.30 | 10.5 |
MDCK | 0.43 ± 0.11 | 0.49 ± 0.14** | 1.1 | 4.32 ± 0.31 | 13.57 ± 2.07* | 3.1 |
BCRP-MDCK | 0.28 ± 0.09 | 1.63 ± 0.09** | 5.8 | 1.31 ± 0.35 | 45.15 ± 0.45 (NS) | 34.5 |
NS, not statistically different from the B-to-A transport in Caco-2.
↵* P < 0.01 and ** P < 0.001, significance level of the difference from the B-to-A transport in Caco-2.