TABLE 1

Summary of kobs and the statistical tests for kobs[I] vs. kobs[0 μM]

A compound is declared to be TDI when at least one p < 0.05.

CompoundConcentrationkobs (S.E.)Significant TDI (p ≤ 0.05)
μM(min−1)
Ketoconazole00.0053 (0.0012)
0.010.0057 (0.0017)No (p = 0.8459)
0.040.0037 (0.0014)No (p = 0.3782)
0.160.0021 (0.0016)No (p = 0.1126)
0.630.0019 (0.0016)No (p = 0.0774)
2.50.0002 (0.0024)No (p = 0.0532)
100.0013 (0.0021)No (p = 0.0890)
Pioglitazone00.0022 (0.0008)
30.0021 (0.0012)No (p = 0.9001)
60.0037 (0.0011)No (p = 0.3080)
100.0044 (0.0008)No (p = 0.0665)
300.0065 (0.0009)Yes (p = 0.0007)
600.0123 (0.001)Yes (p < 0.0001)
800.0161 (0.0016)Yes (p < 0.0001)
Rosiglitazone00.0043 (0.0009)
30.0077 (0.0006)Yes (p = 0.0013)
60.0095 (0.0006)Yes (p < 0.0001)
100.0110 (0.0005)Yes (p < 0.0001)
300.0124 (0.0008)Yes (p < 0.0001)
600.0136 (0.0005)Yes (p < 0.0001)
800.0143 (0.0007)Yes (p < 0.0001)
Raloxifene00.0038 (0.0010)
10.0533 (0.0023)Yes (p < 0.0001)
20.0760 (0.0024)Yes (p < 0.0001)
40.1335 (0.0056)Yes (p < 0.0001)
80.1866 (0.0135)Yes (p < 0.0001)
150.2021 (0.0095)Yes (p < 0.0001)
300.2004 (0.0041)Yes (p < 0.0001)
Erythromycin00.0032 (0.0011)
30.0100 (0.0012)Yes (p < 0.0001)
60.0134 (0.0008)Yes (p < 0.0001)
12.20.0173 (0.0011)Yes (p < 0.0001)
24.60.0221 (0.0016)Yes (p < 0.0001)
49.60.0273 (0.0012)Yes (p < 0.0001)
1000.0293 (0.0016)Yes (p < 0.0001)