TABLE 2
In vitro trapping experiments of the modified Nav1.7 antagonist of the phenyl methyl-isoxazole series
| Compound | Structure | GSH Adduct |
|---|---|---|
| 11 |  | No |
| 12 |  | No |
| 13 |  | No |
| 14 |  | Tracesa |
| 15 |  | No |
| 16 |  | Traces |
| 17 |  | Traces |
| 18 |  | No |
| 19 |  | No |
↵a Trace amounts of a GSH adduct with an increased m/z value of 303 were detected. This adduct is likely formed via aromatic epoxidation and subsequent loss of fluoride occurring on the molecule's right side.