TABLE 6

Thermal hyperalgesia in rats following chronic constriction injurya,b

Following chronic E2072/vehicle daily dosing4 Days after dose cessation7 Days after dose cessation11 Days after dose cessation
E2072 (10 mg/kg per day)−0.55 ± 0.35*−1.36 ± 0.11*−1.53 ± 0.33*−1.9 ± 0.38
Vehicle−3.11 ± 0.34−2.85 ± 0.32−2.68 ± 0.43−2.77 ± 0.3

  • ↵a Data are presented as mean ± S.E.M.; n = 10 rats per dose group.

  • ↵b Withdrawal latencies to thermal stimulus are presented as the difference score in seconds, calculated by subtracting the average latency on the hind paws nonligated vs. ligated side.

  • ↵* P ≤ 0.05 vs. vehicle treated animals.