TABLE 3

Nontrivial correlation estimates for the Michaelis-Menten kinetic parameters using both two- and three-parameter nonlinear models

Compound3pKIkinact2pCkinact2pUkinact
Pioglitazonekobs[0 μM]0.570.57
KI1.00KI1.00KI0.99
Rosiglitazonekobs[0 μM]0.57−0.69
KI0.05KI0.76KI0.72
Raloxifenekobs[0 μM]0.61−0.49
KI0.27KI0.83KI0.83
Erythromycinkobs[0 μM]0.63−0.40
KI0.34KI0.83KI0.80
  • 3p, three-parameter model used to estimate kobs[0 μM], KI, and kinact; 2pC, two-parameter model using corrected kobs to adjust for nonzero kobs[0 μM] estimate; 2pU, two-parameter model using uncorrected estimates for kobs.