JWH-018 Metabolites | CLint in rP450 | Hepatic Abundance | Fractional Contribution of Each P450 (fm, CYP) |
---|---|---|---|
CYP1A2 | |||
ω-OH | 157 | 0.066–0.097 | |
ω-COOH | 23 | 0.045–0.052 | 1.0 |
ω-1-OH | 306 | 0.27–0.36 | |
CYP2C9 | |||
ω-OH | 1035 | 0.83–0.90 | |
ω-COOH | 0 | 0.032–0.073 | 0 |
ω-1-OH | 375 | 0.48–0.62 | |
CYP2C19 | |||
ω-OH | 6.5 | 0.001–0.002 | |
ω-COOH | 0 | 0.006–0.014 | 0 |
ω-1-OH | 48.7 | 0.0011–0.0018 | |
CYP2D6 | |||
ω-OH | 9.3 | 0.001–0.002 | |
ω-COOH | 0 | 0.009–0.01 | 0 |
ω-1-OH | 13.4 | 0.003–0.005 |
rP450, recombinant human cytochrome P450.