TABLE 1

Pharmacokinetics of JM6 and Ro-61-8048 after a single intravenous bolus administration to mice

Analyte Dosed (Dose Level)	Analyte Measured	AUC_last	AUC_inf	AUCN	Cl_p	Vd_ss	MRT	t_1/2
		nM × h		nM × h × kg/mg	l · h⁻¹ · kg⁻¹	l/kg	h
JM6 (5 mg/kg)^{^a}	JM6^{^a}	5200	5200	1000	1.9	0.37	0.20	0.72
	Ro-61-8048	1700	2100	N.C.	N.C.	N.C.	N.C.	N.C.
Ro-61-8048 (5 mg/kg)	Ro-61-8048	510,000	550,000	130,000	0.018	0.15	8.3	6.5