Analyte Dosed (Dose Level) | Analyte Measured | AUClast | AUCinf | AUCN | Clp | Vdss | MRT | t1/2 |
---|---|---|---|---|---|---|---|---|
nM × h | nM × h × kg/mg | l · h−1 · kg−1 | l/kg | h | ||||
JM6 (5 mg/kg)a | JM6a | 5200 | 5200 | 1000 | 1.9 | 0.37 | 0.20 | 0.72 |
Ro-61-8048 | 1700 | 2100 | N.C. | N.C. | N.C. | N.C. | N.C. | |
Ro-61-8048 (5 mg/kg) | Ro-61-8048 | 510,000 | 550,000 | 130,000 | 0.018 | 0.15 | 8.3 | 6.5 |
MRT, mean residence time; N.C., not calculated.
↵a JM6 in the dose contained <0.4% Ro-61-8048.