IC50 values of brivanib and its enantiomer for inhibition of VEFGR-2 and FGFR-1 kinases and for proliferation inhibition of HUVECs stimulated with growth factors
| Compound | IC50 Values | ||||
|---|---|---|---|---|---|
| Kinase Inhibitiona | Proliferation Inhibition of HUVECs Stimulated with Growth Factors | ||||
| VEGFR-2 | FGFR-1 | VEGF | FGF | VEGF & FGF | |
| nM | |||||
| Brivanib | 26 | 28 | 618 | 695 | 841 |
| Enantiomeric metabolite | 20 | 22 | 687 | 1011 | 807 |
↵a IC50 values of brivanib were similar to those reported previously (Bhide et al., 2006).