Mean relative distribution of LY2452473 and metabolites in plasma from healthy male human subjects after oral administration of a single 15-mg (100 μCi) dose of [14C]LY2452473
The AUC0–48 values were calculated using the software Watson (version 7.1) based on nanogram-equivalents per milliliter values of 1-, 2-, 4-, 8-, 24-, and 48-h plasma. The nanogram-equivalents per milliliter value for LY2452473 or each metabolite was calculated by multiplying the percentage of total radioactivity value for each compound with nanogram-equivalents per milliliters of the total radioactivity at a given time point. These values are to be considered semiquantitative only.
| Peak | Total Radioactivity in Plasma | Relative Exposure (AUC0–48) | |||||
|---|---|---|---|---|---|---|---|
| 1 h | 2 h | 4 h | 8 h | 24 h | 48 h | ||
| % | |||||||
| S2 | 0.00 | 0.00 | 0.92 | 0.00 | 0.00 | 0.00 | N.C. |
| S5 | 0.00 | 0.00 | 1.74 | 10.48 | 28.48 | 38.68 | 20.6 |
| S12 | 21.90 | 22.58 | 24.24 | 36.62 | 37.11 | 30.05 | 34.7 |
| S43 | 0.00 | 0.00 | 0.97 | 0.00 | 0.00 | 0.00 | N.C. |
| S60 | 0.00 | 0.89 | 2.20 | 6.94 | 0.00 | 0.00 | 2.3 |
| Parent | 74.50 | 72.93 | 66.33 | 42.36 | 28.81 | 27.67 | 42.2 |
| Total | 96.40 | 96.40 | 96.40 | 96.40 | 94.41 | 96.40 | 100 |
N.C., not calculated.