TABLE 5

E2072 and E2072-homodisulfide rat plasma and tissue concentrations (C_max) following 10 mg/kg E2072 administration for 1 or 5 consecutive days^{^a}

Matrix	E2072 C_max^{^b}		E2072-homodisulfide C_max^{^b}
Matrix	Day 1	Day 5	Day 1	Day 5
Plasma	4922 ± 467	6085 ± 349	240 ± 40	1173 ± 200
Kidney	405 ± 48	388 ± 106	BLQ	23 ± 6
Liver	453 ± 72	457 ± 23	22 ± 10	84 ± 42
Brain	25 ± 3	32.4 ± 21	BLQ	5.5 ± 3.2
Sciatic nerve	203 ± 31	165 ± 30	5.4 ± 1.3	64 ± 15

BLQ, below the limit of quantification.
↵a Data are presented as mean ± S.D.; n = 4 rats per dose group.
↵b Plasma (ng/ml) or tissue (ng/g).