TABLE 2

Pharmacokinetic parameters and oral bioavailability of methoxyflavones after single oral or intravenous administration of 250 mg/kg KP in rats

PK Parameters	Route	PMF	TMF	DMF
AUC (h · μg/ml)	Oral	3.65 ± 0.63^^,^*	6.96 ± 1.11^***	7.01 ± 1.37^***
	IV	76.77 ± 19.50^**	275.66 ± 86.06	233.48 ± 71.57
t_1/2 (h)	Oral	3.12 ± 1.34	5.04 ± 1.10	5.85 ± 1.72
	IV	2.36 ± 1.89	4.19 ± 1.45	3.75 ± 1.01
K_e (h⁻¹)	Oral	0.28 ± 0.17^***	0.15 ± 0.04^***	0.13 ± 0.03^***
	IV	0.61 ± 0.22^*	0.32 ± 0.12	0.32 ± 0.11
Cl (mL/h)	Oral	622.85 ± 114.86^*	337.00 ± 62.17	367.28 ± 82.35
	IV	21.56 ± 7.18^^,^**	6.30 ± 2.17^***	7.98 ± 2.34^***
T_max (h)	Oral	1.71 ± 0.36^*	0.85 ± 0.40	0.76 ± 0.40
C_max (μg/ml)	Oral	0.55 ± 0.05^**	0.88 ± 0.11	0.78 ± 0.11
V_d (ml)	Oral	2637.13 ± 846.59	2385.10 ± 364.37	2957.53 ± 458.19
K_a (h⁻¹)	Oral	1.23 ± 0.54	8.53 ± 3.64	8.69 ± 2.33
Bioavailability (%)		3.32	1.75	2.10

Data are expressed as mean ± S.D. (n = 10). IV, intravenous.
↵* Polyethylene glycol 400: significant higher than the others in the same route at P < 0.05.
↵** Significance lower than the others in the same route, P < 0.05.
↵*** Significance lower than the other route.