PK Parameters | Route | PMF | TMF | DMF |
---|---|---|---|---|
AUC (h · μg/ml) | Oral | 3.65 ± 0.63**,*** | 6.96 ± 1.11*** | 7.01 ± 1.37*** |
IV | 76.77 ± 19.50** | 275.66 ± 86.06 | 233.48 ± 71.57 | |
t1/2 (h) | Oral | 3.12 ± 1.34 | 5.04 ± 1.10 | 5.85 ± 1.72 |
IV | 2.36 ± 1.89 | 4.19 ± 1.45 | 3.75 ± 1.01 | |
Ke (h−1) | Oral | 0.28 ± 0.17*** | 0.15 ± 0.04*** | 0.13 ± 0.03*** |
IV | 0.61 ± 0.22* | 0.32 ± 0.12 | 0.32 ± 0.11 | |
Cl (mL/h) | Oral | 622.85 ± 114.86* | 337.00 ± 62.17 | 367.28 ± 82.35 |
IV | 21.56 ± 7.18*,*** | 6.30 ± 2.17*** | 7.98 ± 2.34*** | |
Tmax (h) | Oral | 1.71 ± 0.36* | 0.85 ± 0.40 | 0.76 ± 0.40 |
Cmax (μg/ml) | Oral | 0.55 ± 0.05** | 0.88 ± 0.11 | 0.78 ± 0.11 |
Vd (ml) | Oral | 2637.13 ± 846.59 | 2385.10 ± 364.37 | 2957.53 ± 458.19 |
Ka (h−1) | Oral | 1.23 ± 0.54 | 8.53 ± 3.64 | 8.69 ± 2.33 |
Bioavailability (%) | 3.32 | 1.75 | 2.10 |