TABLE 3

Coupling efficiency of CYP1A1 and CYP1A2 at different branching points of the P450 cycle

Ratios were calculated from the parameters in Table 2.

EnzymeProduct/NADPHaH2O2/O2bH2O/Productc
CYP1A10.0250.3728.71
CYP1A20.0510.626.82

  • ↵a Efficiency of the coupling of reducing equivalents to product formation.

  • ↵b Reflects uncoupling at the first or second branch point.

  • ↵c Reflects uncoupling at the third branch point.