Post-HIPEC levels of free doxorubicin in peritoneum or ovarian carcinomatosis
In these samples, total doxorubicin consisted of free doxorubicin only. Biopsy specimens were obtained by inspecting the abdominal cavity at 2 to 3 min after HIPEC ended. Patients were coded as in Table 1. Two samples of normal peritoneum were obtained from patients 3 and 5; one carcinomatosis nodule was obtained from patient 3.
| Sample | Tissue-Free Doxorubicin | ||||
|---|---|---|---|---|---|
| Pt 2 | Pt 3 | Pt 5 | Pt 6, Pt 7 | Pt 2 | |
| nmol/g | |||||
| Normal peritoneum | 10.2 | 0.51–0.46 | 1.2–4.1 | 11.5 | 12.5 |
| Ovarian peritoneal carcinomatosis | N.A. | 0.44 | N.A. | N.A. | N.A. |
Pt, patient; N.A., not available.