Pharmacokinetic Parameter | Day −7 (n = 17) | Day 1 (n = 17) | Day 16 (n = 12) |
---|---|---|---|
Cmax (ng/ml) | 16.3 ± 7.6 | 15.7 ± 6.2 | 16.0 ± 7.7 |
AUClast (h·ng/ml) | 49.8 ± 30.9 | 47.3 ± 26.4 | 48.4 ± 23.0 |
AUC0–12 (h·ng/ml) | 42.5 ± 23.2 | 40.3 ± 19.1 | 48.4 ± 23.0 |
AUCinf (h·ng/ml)a | 54.3 ± 36.0 | 51.5 ± 30.3 | 59.9 ± 32.5 |
Tmax (h) | 0.5 ± 0.2 | 0.7 ± 0.3 | 0.8 ± 0.7 |
t1/2 (h)a | 6.6 ± 2.2 | 6.3 ± 1.9 | 5.5 ± 1.5 |
↵a n = 11 on day 16 for AUCinf and t1/2.