TABLE 4

Proposed structures and metabolic pathways of metabolites in rat urine and feces after administration of 750 mg/kg KP

No.[M + H]+1Fragment Ions in MS/MSStructure of Proposed MetabolitesReactionsSourcePossible Substrate of the Metabolite
M1255239.11Embedded ImageDemethylationUrine/fecesDMF
M2285269.01Embedded ImageDemethylationUrine/fecesTMF
M3315298.67
285.17
270.75
256.33		Embedded ImageDemethylationUrine/feces3,5,7,4′-Tetramethoxyflavone
M4345328.17
311.45
298.60
284.55
277.41
255.68
237.61		Embedded ImageDemethylationUrine/fecesPMF
M5349268.78
254.26		Embedded ImageDemethylation, sulfationUrineDMF
M6359343.03
328.41
297.66
282.49
254.62		Embedded ImageDemethylationUrinePMF
M7365284.92
269.24
255.09		Embedded ImageDemethylation, sulfationUrineTMF
M8379298.38
284.37
269.17
254.87		Embedded ImageDemethylation, sulfationUrineTMF
M9415238.65Embedded ImageGlucuronidationUrineDMF
M10301285.00
269.52
256.01		Embedded ImageDemethylationFeces3,5,7,4′-Tetramethoxyflavone
M11331315.49
299.97
285.69
268.42
255.94		Embedded ImageDemethylationFecesPMF