TABLE 1

Experimental groups for evaluating rituximab pharmacokinetics in rats

Rituximab			Modifier
Route	Site	Dose	Drug	Site	Dose
i.v.	Tail vein	10 mg/kg	IgG	Back	500 mg/kg
s.c.	Back	1 mg/kg^{^a}	IgG	Back	500 mg/kg
s.c.	Back	10 mg/kg	IgG	Back	500 mg/kg
s.c.	Abdomen	1 mg/kg^{^a}	IgG	Abdomen	500 mg/kg
s.c.	Abdomen	10 mg/kg	IgG	Abdomen	500 mg/kg
s.c.	Back	1 mg/kg^{^a}	Hyaluronidase	Back	100 IU/kg
s.c.	Back	10 mg/kg	Hyaluronidase	Back	100 IU/kg
s.c.	Abdomen	10 mg/kg	Hyaluronidase	Abdomen	100 IU/kg
s.c.	Back	40 (infusion)	—	—	—

↵^a Commercially available formulation (10 mg/ml) diluted with normal saline.