TABLE 1

Pharmacokinetic parameters of LO and/or laninamivir in ELF, lungs, and plasma after a single intranasal administration of LO and laninamivir to mice.

Each value was calculated based on the mean concentration derived from three or four animals at each time point.

Test Compound	Matrix	Analyte	C_max	T_max	t_1/2	AUC_last
			pmol/ml or g	h	h	pmol⋅h/ml or g
LO	ELF	LO	20,400^**	0.033^*	1.1	23,600
		Laninamivir	1520	1	25.1	26,500
	Lungs	LO	1760	0.5	1.3	4480
		Laninamivir	4350	6	30.9	75,800
	Plasma	LO	242	0.5	0.6	323
		Laninamivir	181	1	13.1	445
Laninamivir	ELF	Laninamivir	19,900^**	0.033^*	25.4	19,600
	Lungs	Laninamivir	1020	0.25	25.0	9890
	Plasma	Laninamivir	478	0.5	NC	782