TABLE 2

Final pharmacokinetic model-estimated parameters

Further details on the parameters are available in Materials and Methods.

ParameterUnitsModel AModel B
Mean%CVMean%CV
Vcl/kg6.10·10−2aFixed6.43·10−24
k12day−10.479aFixedN/A
k21day−10.305aFixedN/A
kelday−10.137aFixedN/A
Graphicday−10.513aFixed0.50010
Graphicnmol10.9aFixed10.318
Graphicnmol3.00aFixed2.7121
kinjday−139.9aFixed37.516
ka2day−10.295aFixed0.3199
ka1 backday−16.30·10−2aFixed6.88·10−29
ka1 abdomenday−10.242aFixed0.2598
ka1 back + hyaluronidaseday−10.3736Not estimated
ka1 abdomen + hyaluronidaseday−12.618Not estimated
kupday−1N/A0.65510
kretday−1N/A0.32012
Graphicday−1N/A0.3144
GraphicnMN/A8.30·104bFixed
GraphicnMN/A500bFixed
GraphicnMN/A1.03·105bFixed
  • %CV, percent coefficient of variation; N/A, not applicable;

  • a Fixed to values previously published by Kagan et al. (2012).

  • b Fixed to values published previously by Hansen and Balthasar (2003).