Intrinsic liver microsomal clearance (CLint, μl/min⋅mg) of compound 1 in liver microsomes
| Concentration | Mouse +NADPH | Rat +NADPH | Dog +NADPH | Human +NADPH | Mouse −NADPH |
|---|---|---|---|---|---|
| 0.1 μM | 891 | 14 | 51 | 93 | 805 |
| 1 μM | 110 | 13 | 33 | 67 | 50 |
CLint in rat, dog, and human −NADPH was <5 μl/min⋅mg.