TABLE 1

Degree of DNA methylation around the TSS of mouse Oatps

The percentage was calculated by dividing the total number of methylated CpGs by that of all CpGs analyzed in bisulfite sequencing. Differences in the methylation status of entire region between the tissues were statistically analyzed using Fisher’s exact test followed by Bonferroni adjustment to correct for multiple testing.

Tissue	Degree of DNA Methylation (%)
Tissue	Oatp1c1	Oatp1b2^*,^{^†}	Oatp1a4^*,^{^‡}	Oatp1a1^{^†}	Oatp1a6^*,^{^‡}
Liver	60	20	26	27	85
Kidney	50	73	73	60	20
Cerebrum	37	88	51	80	65
Brain capillary-enriched fraction	20	—	26	—	—

↵* P < 0.05 between liver and kidney.
↵† P < 0.05 between liver and cerebrum.
↵‡ P < 0.05 between kidney and cerebrum.