TABLE 1

Mean noncompartmental pharmacokinetics parameters for ALK inhibitors after 2 mg/kg i.v. administration to mice

A total of 27 animals (3 per time point) were used to generate the data for each compound.

Compound	AUC_0-inf	CL	MRT	t_1/2	V_ss
	μM⋅h	l/h⋅kg	h	h	l/kg
1	0.627	5.52	0.474	1.05	2.62
2	0.957	3.51	1.28	1.01	4.49
3	1.53	2.14	2.56	2.08	5.47
4	1.20	2.66	2.92	2.20	7.78