Cocktail | T1/2 | Ke | AUC | CL |
---|---|---|---|---|
h | ×103 min−1 | h × ng/ml | ml/h | |
Caffeine (CYP1A2) | ||||
Sham | 4.8 ± 2.0 | 2.7 ± 1.0 | 279.7 ± 25.3 | 1.86 ± 0.15 |
rHSA | 5.1 ± 2.3 | 2.1 ± 0.9 | 384.5 ± 71.3 | 1.54 ± 0.48 |
RBC | 8.2 ± 3.3* | 1.6 ± 0.8* | 509.6 ± 82.7** | 1.04 ± 0.16** |
CO-RBC | 5.4 ± 3.7 | 1.4 ± 0.2 | 406.1 ± 4.9 | 1.28 ± 0.09 |
Tolbutamide (CYP2C11) | ||||
Sham | 2.7 ± 0.6 | 4.5 ± 1.0 | 222.4 ± 43.1 | 2.39 ± 0.40 |
rHSA | 2.8 ± 1.4 | 4.2 ± 0.7 | 264.4 ± 40.2 | 2.15 ± 0.56 |
RBC | 6.8 ± 0.7** | 1.7 ± 0.2** | 402.1 ± 39.0** | 1.29 ± 0.13** |
CO-RBC | 2.9 ± 0.6 | 4.0 ± 0.7 | 255.3 ± 36.9 | 2.07 ± 0.31 |
Chlorzoxazone (CYP2E1) | ||||
Sham | 4.8 ± 1.1 | 2.5 ± 0.6 | 287.3 ± 61.5 | 1.87 ± 0.36 |
rHSA | 3.6 ± 1.3 | 3.2 ± 1.1 | 304.8 ± 41.5 | 1.77 ± 0.44 |
RBC | 6.7 ± 0.9** | 1.7 ± 0.2** | 593.0 ± 64.8** | 0.95 ± 0.12** |
CO-RBC | 3.3 ± 0.8 | 3.6 ± 0.8 | 315.9 ± 95.0 | 1.73 ± 0.37 |
Midazolam (CYP3A2) | ||||
Sham | 3.2 ± 0.4 | 3.7 ± 0.4 | 211.3 ± 19.2 | 2.47 ± 0.24 |
rHSA | 3.6 ± 1.7 | 3.6 ± 1.4 | 316.4 ± 73.2 | 1.62 ± 0.86 |
RBC | 4.5 ± 1.2* | 2.7 ± 0.6* | 496.5 ± 116.1** | 1.08 ± 0.22** |
CO-RBC | 3.2 ± 0.7 | 3.7 ± 0.7 | 293.8 ± 14.8 | 1.78 ± 0.16 |