Clinically observed and Simcyp-predicted pharmacokinetic parameter estimates of crizotinib in humans after a single or 28-day repeated oral administration of crizotinib
Data are expressed as geometric mean (% coefficient of variation) for single dose (n = 8 patients) and 28-day repeated doses (n = 5 patients).
↵a Simcyp simulation was performed using TDI parameters from either HLM or HSP.
↵b Calculated mean ratio of predicted to observed pharmacokinetic parameters.