TABLE 1

Relative sensitivities to C-1305 and C-1311 of untransfected or transfected KB-3 cells lines

The IC50 values shown represent mean ± S.D. (n = 8 for C-1305 and n = 5 for C-1311) and were derived from cell viability curves as in Fig. 5.

CompoundCell LineIC50
MeanSD
μM
C-1305KB-30.2630.016***
KB-3 UGT1A100.1800.014
KB-3 pcDNA3.10.2600.020***
KB-3 UGT2B40.2610.028***
C-1311KB-30.1060.014*
KB-3 UGT1A100.1310.008
KB-3 pcDNA3.10.1020.008*
KB-3 UGT2B40.1130.018a

  • ↵*** Significantly different from KB-3 UGT1A10, P < 0.0005; *Significantly different from KB-3 UGT1A10, P < 0.01.

  • ↵a Not significantly different from KB-3 UGT1A10, P > 0.05.