Prediction accuracies of CL, Vss, and t1/2 of 15 model compounds in each group using the hybrid approach
| Group | n | Exponent | afe | |||
|---|---|---|---|---|---|---|
| CL | Vss | CL | Vss | t1/2 | ||
| 1 | 6 | 0.7–1.1 | 0.7 – 1.1 | 1.29 | 1.40 | 1.89 |
| 2 | 3 | 0.7–1.1 | < 0.7 and > 1.1 | 1.44 | 2.64 | 2.20 |
| 3 | 4 | <0.7 and >1.1 | 0.7 – 1.1 | 2.81 | 1.30 | 2.31 |
Group 1, antipyrine, caffeine, epiroprim, propafenone, theophylline, verapamil; Group 2, felodipine, propranolol, tolcapone; Group 3, diltiazem, midazolam, nicardipine, oxazepam.