TABLE 1

Gestational age-dependent changes of metabolic enzyme and transporter genes in the maternal liver

This list of Cyp, Sult, Ugt, Abc, Slc, and Slco genes was generated using the following filtration criteria: fold change >1.5 or <0.65, unadjusted P < 0.05, and log₂ average fluorescent intensity >4 on at least one gestation day (gd). Shown are fold changes compared with gd 0. Fold change is defined as the ratio of fluorescent intensity of the gene on a gestation day to that on gd 0. P values are unadjusted.

Gene Symbol	gd 7.5		gd 10		gd 15		gd 19
Gene Symbol	Fold Change	P	Fold Change	P	Fold Change	P	Fold Change	P
Cyp2b13	0.7	0.024	0.5	<0.001	0.3	<0.001	0.3	<0.001
Cyp2c50	0.9	0.133	0.6	<0.001	0.4	<0.001	0.5	<0.001
Cyp2c54	0.9	0.047	0.7	<0.001	0.6	<0.001	0.7	<0.001
Cyp2c55	0.8	0.302	0.8	0.284	0.5	0.001	0.7	0.033
Cyp2d9	0.7	<0.001	0.5	<0.001	0.5	<0.001	0.6	<0.001
Cyp2d40	1.0	0.808	1.5	0.002	1.7	<0.001	1.9	<0.001
Cyp2g1	1.0	0.66	1.2	0.094	1.6	<0.001	1.2	0.027
Cyp3a16	1.4	<0.001	1.4	<0.001	1.6	<0.001	1.4	<0.001
Cyp4a12a	0.2	<0.001	0.3	<0.001	0.2	<0.001	0.2	<0.001
Cyp4a12b	0.3	<0.001	0.3	<0.001	0.3	<0.001	0.3	<0.001
Cyp4a14	1.7	0.24	1.3	0.598	0.3	0.021	0.6	0.237
Cyp4a31	1.5	0.004	1.6	0.002	1.8	<0.001	1.9	<0.001
Cyp4f15	0.9	0.242	0.7	<0.001	0.6	<0.001	0.8	0.066
Cyp7b1	1.5	0.003	1.3	0.046	1.5	0.002	1.5	0.006
Cyp8b1	0.9	0.322	1.1	0.598	1.4	0.064	1.6	0.006
Cyp17a1	3.3	<0.001	3.3	<0.001	8.2	<0.001	10.4	<0.001
Cyp26a1	1.0	0.962	2.1	0.082	2.9	0.015	1.1	0.752
Cyp39a1	0.8	0.103	0.5	<0.001	0.3	<0.001	0.4	<0.001
Cyp51	1.0	0.84	0.8	0.176	0.8	0.069	0.6	0.001
Sult1d1	0.9	0.195	0.6	<0.001	0.4	<0.001	0.7	0.021
Ugt2b37	1.5	0.004	1.5	0.005	0.9	0.354	1.0	0.836
Abca8a	0.9	0.249	0.7	0.018	0.5	<0.001	0.8	0.103
Abcb1a	1.1	0.431	0.9	0.573	0.6	0.008	0.9	0.356
Abcb6	0.9	0.032	0.8	0.006	0.6	<0.001	0.8	<0.001
Abcc3	0.9	0.412	0.7	0.01	0.3	<0.001	0.4	<0.001
Abcg5	0.8	0.157	0.7	0.013	0.6	<0.001	0.8	0.092
Abcg8	0.8	0.259	0.6	0.002	0.8	0.134	1.0	0.815
Slc1a2	0.9	0.362	1.1	0.329	1.7	<0.001	2.1	<0.001
Slc3a1	1.7	0.009	1.7	0.007	1.8	0.003	2.1	0.001
Slc6a9	1.1	0.612	2.1	<0.001	4.3	<0.001	2.8	<0.001
Slc7a2	0.7	0.014	0.5	<0.001	0.6	0.001	0.7	0.068
Slc7a8	1.3	0.005	1.5	<0.001	1.2	0.023	1.0	0.979
Slc9a3r1	1.0	0.843	0.9	0.419	0.6	<0.001	0.8	0.009
Slc13a2	1.0	0.663	1.2	0.162	1.5	<0.001	1.1	0.564
Slc15a1	1.0	0.832	0.9	0.542	1.7	0.018	1.0	0.897
Slc15a4	0.7	0.006	0.6	<0.001	0.6	<0.001	0.8	0.029
Slc16a1	1.1	0.422	1.4	0.002	1.7	<0.001	1.3	0.018
Slc16a12	1.0	0.932	0.7	0.002	0.4	<0.001	0.7	0.009
Slc16a13	0.9	0.237	1.2	0.011	1.6	<0.001	1.3	0.001
Slc16a6	1.2	0.363	3.4	<0.001	8.9	<0.001	2.7	<0.001
Slc17a1	1.0	0.658	0.8	0.057	0.5	<0.001	0.7	<0.001
Slc17a2	1.0	0.872	0.7	0.002	0.4	<0.001	0.6	<0.001
Slc17a4	0.8	0.036	1.4	0.003	1.6	<0.001	1.3	0.01
Slc17a8	0.7	0.009	0.6	0.001	0.6	<0.001	0.7	0.012
Slc19a2	0.8	0.103	0.7	0.003	0.6	<0.001	0.9	0.181
Slc22a15	0.9	0.131	0.8	0.024	0.6	<0.001	0.9	0.083
Slc22a2	1.1	0.677	1.0	0.978	3.6	<0.001	1.9	<0.001
Slc22a23	1.1	0.484	1.1	0.389	1.6	<0.001	1.2	0.008
Slc24a3	0.9	0.426	0.9	0.314	1.7	<0.001	1.3	0.009
Slc24a6	1.1	0.579	0.5	<0.001	0.5	<0.001	1.2	0.295
Slc25a4	0.6	0.005	0.8	0.116	0.7	0.008	0.6	0.004
Slc25a25	0.7	0.223	1.0	0.898	1.3	0.31	0.6	0.026
Slc25a30	1.5	0.011	1.3	0.092	1.8	<0.001	1.4	0.019
Slc25a32	0.7	0.006	0.7	0.002	0.6	<0.001	0.8	0.057
Slc25a47	0.8	0.063	0.6	0.001	0.5	<0.001	0.8	0.226
Slc30a10	1.2	0.118	1.5	0.001	1.1	0.362	0.9	0.288
Slc34a2	1.3	0.211	2.6	<0.001	1.7	0.034	1.1	0.657
Slc35c2	0.9	0.215	1.2	0.013	1.7	<0.001	1.5	<0.001
Slc36a1	1.1	0.161	1.5	<0.001	2.1	<0.001	1.5	<0.001
Slc37a1	1.5	0.018	2.5	<0.001	4.0	<0.001	1.9	<0.001
Slc37a4	0.8	0.028	0.8	0.052	0.6	<0.001	0.9	0.452
Slc38a4	0.9	0.216	0.7	0.001	0.4	<0.001	0.6	<0.001
Slc39a14	1.1	0.213	1.4	0.001	1.7	<0.001	1.3	0.022
Slc39a4	0.8	0.011	0.8	0.002	0.6	<0.001	0.8	<0.001
Slc40a1	1.0	0.732	1.1	0.054	1.5	<0.001	1.0	0.988
Slc41a1	1.3	0.011	1.6	<0.001	1.6	<0.001	1.3	0.01
Slc41a2	1.8	0.073	5.2	<0.001	8.3	<0.001	3.7	<0.001
Slc41a3	1.1	0.159	1.2	0.06	1.6	<0.001	2.2	<0.001
Slc43a1	1.0	0.813	1.3	0.008	1.7	<0.001	1.7	<0.001
Slc43a3	1.1	0.375	1.0	0.69	0.6	<0.001	0.7	<0.001
Slc46a3	0.9	0.123	0.8	0.02	0.5	<0.001	0.8	0.006
Slco1a4	1.0	0.901	0.8	0.074	0.5	<0.001	0.9	0.367