Summary of immunohistochemical localization of drug transporters in human ocular tissues
| Ocular Tissue | PEPT | OCT | MCT | ATB0,+ | |||
|---|---|---|---|---|---|---|---|
| PEPT-1 | PEPT-2 | OCT-1 | OCT-2 | MCT-1 | MCT-3 | ||
| Cornea | + | + | + | + | + | − | + |
| Conjunctiva | + | + | + | + | + | − | + |
| Ciliary epithelium | + | + | + | − | + | − | + |
| Choroidal smooth muscle | + | + | + | − | − | − | − |
| Retinal pigmented epithelium | + | + | + | − | − | + | − |
| Outer segment of photoreceptor cells | − | + | − | − | + | − | − |
| Inner segment of photoreceptor cells | − | + | + | − | − | − | − |
| Outer nuclear layer | − | − | − | − | − | − | + |
| Inner nuclear layer | − | − | − | − | − | − | + |
| Outer plexiform layer | + | − | − | − | − | − | − |
| Inner plexiform layer | − | − | − | − | − | − | − |
| Ganglion cell layer | + | + | − | − | − | − | + |
| Inner limiting membrane | − | − | − | − | + | − | − |
ATB0,+, neutral and basic amino acid transporter; MCT, monocarboxylate transporter; OCT, organic cation transporter; PEPT, peptide transporter. (+) indicates the immunostaining based presence and (−) indicates immunostaining based absence of transporter expression.