Human CLbile | Human CLbile,u | Rat CLbile | Rat CLbile,u | Dog CLbile | Dog CLbile,u | |
---|---|---|---|---|---|---|
Doxorubicin | 2.035a | 7.268 | 3.68b | 10.82 | 1.720c | 5.059 |
Digoxin | 1.595d | 2.279 | 3.03e | 4.329 | 1.313f | 2.680 |
Erythromycin | 1.147g | 7.169 | 17.4h | 22.38 | 2.376i | 4.483 |
Cefazolin | 0.001j | 0.007 | 1.40k | 11.24 | 0.066l | 0.089 |
Cefamandole | 0.012m | 0.048 | 5.00n | 29.41 | ||
Cephalexin | 0.0134o | 0.016 | 1.07o | 1.408 | ||
Cefotetan | 0.048o | 0.320 | 6.14o | 8.771 | 0.696o | 1.141 |
Cefixime | 0.140p | 0.452 | 1.00q | 7.143 | ||
Ceftriaxone | 0.070r | 0.933 | 0.82s | 12.73 | 2.5s | 2.907 |
Cefpiramide | 0.040t | 1.000 | 5.22u | 9.667 | 0.979v | 1.399 |
Cefoperazone | 0.149w | 2.129 | 16.3x | 22.03 | ||
Valsartan | 0.431y | 10.775 | 12.5z | 378.8 | ||
Moxalactam | 0.003aa | 0.008 | 2.19ab | 4.294 | ||
Methotrexate | 0.048o | 1.108 | 9.60o | 12.47 | 0.217o | 0.344 |
Pravastatin | 3.105ac | 6.210 | 27.5ad | 78.57 | ||
Diclofenac | 0.042ae | 8.400 | 0.85af | 94.44 | ||
Ranitidine | 0.153ag | 0.161 | 1.40o | 1.556 | ||
Vincristine | 0.209ah | 0.523 | 33.1e | 84.87 | ||
Methadone | 0.001ai | 0.006 | 5.22aj | 14.33 | ||
Fexofenadine | 1.400ak | 4.000 | 8.00al | 42.11 | ||
Ciprofloxacin | 0.059am | 0.084 | 3.50an | 6.140 | ||
Napsagatran | 4.357o | 7.922 | 34.7o | 105.2 | 32.75o | 62.98 |
↵a Wilkinson et. al., 1979.
↵b Krishna et al., 1999.
↵c Iguchi et al., 1986.
↵d Hedman et. al., 1991.
↵e Song et al., 1999.
↵f Miyazawa et al., 1990.
↵g Takimura and Lopez-Belio, 1955.
↵h Lam et al., 2006.
↵i Wyman et al., 1968.
↵j Brogard et. al., 1984.
↵k Tsuji et al., 1983.
↵l Yoshikawa et al., 1979.
↵m Ratzan et al., 1978.
↵n Wright and Line, 1980.
↵o Morris et al., 2012.
↵p Westphal et al., 1993.
↵q Yasui et al., 1994.
↵r Arvidsson et al., 1982.
↵s Matsui et al., 1984.
↵t Brogard et al., 1988.
↵u Muraoka et al., 1995.
↵v Matsui et al., 1982.
↵w Kemmerich et al., 1983.
↵x Saikawa et al., 1980.
↵y Brookman et al., 1997.
↵z Yamashiro et al., 2006.
aa Uchida et al., 1985.
ab Mizojiri et al., 1987.
ac Sasaki et al., 2004.
ad Hatanaka et al., 1998.
ae Stierlin and Faigle., 1979.
af Peris-Ribera et al., 1991.
ag Klotz and Walker., 1990.
ah Jackson et al., 1978.
ai Kreek et al., 1980.
aj Sutfin et al., 1987.
ak ALLEGRA Product Monograph, sanofi-aventis Canada Inc., products.sanofi.ca/en/allegra.pdf and Wang et al., 2002.
al Tahara et al., 2005 Jaisue et al., 2010.
am Tanimura et. al., 1986.
an Yamaguchi et al., 2004.