Characterization of changes in dextromethorphan metabolism in mouse liver during gestation
The incubations were conducted as described in Materials and Methods.
| Michaelis-Menten Parameters for Dextrorphan Formation in MLH from Pregnant and Nonpregnant mice | |||
|---|---|---|---|
| Gestational Age | Vmax | Km | CLint |
| pmol/min/mg protein | µM | µl/min/mg protein | |
| Nonpregnant (n = 3) | 25.4 ± 1.0 | 2.5 ± 0.5 | 10.1 ± 2.1 |
| 15 days (n = 2) | 26.6 ± 1.6 | 3.4 ± 1.0 | 7.9 ± 2.3 |
| 19 days (n = 2) | 32.3 ± 0.7* | 3.5 ± 0.4 | 9.2 ± 1.0 |
↵* Indicates statistical significance at P < 0.05 compared with nonpregnant and GD15 mice.