Portal and systemic exposure of loperamide in P-gp–competent or P-gp–deficient mice
| AUC | |||
|---|---|---|---|
| Dose | 0.23 mg/kg | 0.47 mg/kg | 0.96 mg/kg |
| ng*min/ml | |||
| Portal exposure | |||
| P-gp-competent | 270 ± 77 | 270 ± 140 | 4900 ± 3000 |
| P-gp-deficient | 90 ± 14 | 420 ± 54 | 5700 ± 2900 |
| Systemic exposure | |||
| P-gp-competent | 56 ± 16 | 31 ± 11 | — |
| P-gp-deficient | 62 ± 23 | 260 ± 120 | — |
AUC, area under the curve; P-gp, P-glycoprotein.