TABLE 1

Metabolite cut-off value versus the metabolite/parent inhibition potency ratio

[Im]/[Ip]Kim/Kip
1.5 (150%)1/1
1 (100%)2/3
0.5 (50%)1/3
0.25 (25%)1/6

  • [Im]/[Ip], metabolite to parent ratio; Kim/Kip, metabolite/parent inhibition potency ratio.