TABLE 4
Inhibition potential of digoxin transport by apixaban in Caco-2 cells
Digoxin
Apixaban
Pc
A-B, app
Pc
B-A, app
Pc
Difference
% Inhibition of Digoxin Efflux
μM
μM
nm/s
nm/s
nm/s
5
0
6 ± 1
140 ± 9
134
0
5
50
18 ± 10
144 ± 6
126
5.9
5
25
5 ± 0.2
126 ± 33
121
9.9
5
12.5
7 ± 3.5
139 ± 10
132
1.5