Inhibition potential of digoxin transport by apixaban in Caco-2 cells
| Digoxin | Apixaban | PcA-B, app | PcB-A, app | Pc Difference | % Inhibition of Digoxin Efflux |
|---|---|---|---|---|---|
| μM | μM | nm/s | nm/s | nm/s | |
| 5 | 0 | 6 ± 1 | 140 ± 9 | 134 | 0 |
| 5 | 50 | 18 ± 10 | 144 ± 6 | 126 | 5.9 |
| 5 | 25 | 5 ± 0.2 | 126 ± 33 | 121 | 9.9 |
| 5 | 12.5 | 7 ± 3.5 | 139 ± 10 | 132 | 1.5 |